Merkel Cell Cancer: Poor Response To Chemotherapy Exposes Significant Unmet Need
نویسندگان
چکیده
منابع مشابه
Metastatic Merkel cell carcinoma response to nivolumab
BACKGROUND Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy with limited treatment options. Several lines of evidence support the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis as a likely contributor to immune evasion in MCC. CASE PRESENTATION We report a case of a patient with metastatic MCC with a significant and durable response to nivolumab...
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While pleural effusion in multiple myeloma is relatively infrequent, myelomatous pleural effusion is extremely rare. We experienced a 61-year-old woman with IgD-lambda multiple myeloma and pleural effusion. The diagnosis was made originally by pleural biopsy, pleural fluid cytology and immunoelectropheresis of pleural fluid. Transient improvement of the pleural effusion was observed after admin...
متن کاملSignificant overexpression of the Merkel cell polyomavirus (MCPyV) large T antigen in Merkel cell carcinoma.
BACKGROUND The purpose of this study was to determine the expression pattern of the Merkel cell polyomavirus (MCPyV) large T-protein antigen in patients with Merkel cell carcinoma. METHODS A tissue microarray (TMA) containing 30 specimens was constructed and stained for the MCPyV large T protein. Immunohistochemical expression was determined semiquantitively and was compared to patients' outc...
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Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma protein-binding motif. We confirm here that YM155, a survivin suppressor, is cytotoxic to MCV-positiv...
متن کاملErratum to: Metastatic Merkel cell carcinoma response to nivolumab
[This corrects the article DOI: 10.1186/s40425-016-0186-1.].
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ژورنال
عنوان ژورنال: Value in Health
سال: 2017
ISSN: 1098-3015
DOI: 10.1016/j.jval.2017.08.102